Limitations of QTL Mapping.PDF
نویسندگان
چکیده
Beavis’ (1998) study on “power, precision, and accuracy” of QTL mapping is a classic. His work (first reported at a symposium in 1994) was the first demonstration of the effects of small sample sizes on the reliability of QTL mapping. This work demonstrated that when sample sizes (n) were small, power to detect true QTL was low, and the bias in the estimated proportion of the genetic variance explained by mapped QTLs was huge:
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